Alteration of norepinephrine release from (3H)-norepinephrine preloaded basilar artery by naphthalenesulfonamides.
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چکیده
منابع مشابه
Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine.
To study the mechanism by which norepinephrine acts on vascular muscle cell membrane, we recorded membrane potential with intracellular microelectrodes in isolated cat basilar and pial arteries. On addition of norepinephrine concentrations less than 1 microM, pial arteries hyperpolarized and relaxed while basilar arteries depolarized and contracted. Relaxation and hyperpolarization of the pial ...
متن کاملPlasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension.
We infused tracer-labeled l-[3H]-norepinephrine, d-[14C]norepinephrine, and d,l-[3H]-isoproterenol simultaneously into patients with essential hypertension and into normotensive control subjects, in order to determine whether abnormalities in the disappearance kinetics of these substances characterized the hypertensive patients. The mean preinfusion venous plasma norepinephrine concentration wa...
متن کاملCharacterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes.
Nicotine's modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown. In the present study, we used a number of subtype-selective alpha-conotoxins in combination with nicotinic receptor subunit-deficient mice to characterize nAChRs tha...
متن کاملExpression of the Capacity to Release [3h]norepinephrine by Neural Crest Cultures1
Cultures of trunk neural crest cells from quail embryos were tested for their ability to release [3H]norepinephrine ([3H]NE) in response to depolarization. After 7 days in. uitro, exposure of the cultures to either the alkaloid veratridine or 40 mM K+ results in the evoked release of [3H]NE. The release evoked by veratridine is blocked in the presence of tetrodotoxin. The release evoked by incr...
متن کاملCharacterization of norepinephrine-induced contractile response in isolated rabbit basilar artery.
It is well known that a-adrenoceptors have been classified into the a1-type in postsynaptic sites and the a2-type in presynaptic sites (1). Prazosin and yohimbine are selective an tagonists of a1 and a2-adrenoceptors, re spectively (2). Norepinephrine (NE) exerts a non-selective agonistic action at each type of a-adrenoceptors (3, 4). Recent reports present evidence that postsynaptic a2 as well...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.32.615